Research Page of Kris De Braekeleer

Civil status
- Born 27 April 1972 in Ninove (Belgium)
Education
- Pharmacist 1995 - VUB
- Phd in Pharmaceutical Sciences 1999 - VUB Department of Pharmaceutical and Biomedical Analysis (FABI) - Title thesis: Multivariate Techniques for Purity Assessment and Pharmaceutical Reaction Monitoring, Promotor: Prof. Dr. D.L. Massart
Experience
- 1/10/1995-1/10/1999: Assistant at the VUB Deparment of Pharmaceutical and Biomedical Analysis (FABI): teaching tasks
- 15/07/1997-31/07/1997: Research stage in the group of chemometrics of the Department of Analytical Chemistry of the University of Barcelona
- 1/10/1999-31/12/1999: EU project (27 September 1999) on N-way methods for product quality control and process analysers applied to batch processes. The partners in this project are Elf Antar France (dr. P. Ricoux - Centre de Recherche de Solaize), The Royal Veterinary and Agricultural University of Denmark (Dept. of dr. C. Andersson) and the VUB.
- 1/01/00-...: Post-doc position at Pfizer Global Research and Development, Sandwich, Kent
Research Topics
- Chemometrics (Multivariate mixture analysis, Multivariate curve resolution alternating least squares)
- Analytical Chemistry (high-performance liquid chromatography diode array detection)
Publications
- Evaluation of the orthogonal projection approach (OPA) and the SIMPLISMA approach on the Windig standard spectral data sets
  K. De Braekeleer and D.L. Massart
  Chemometrics and Intelligent Laboratory Systems 39 (1997), 127-141
  Read the abstract of this article
- Influence and correction of temperature perturbations on NIR spectra during the monitoring of a polymorph conversion process prior to self-modelling mixture analysis
  K. De Braekeleer, F. Cuesta Sánchez, P.A. Hailey, D.C.A. Sharp, A.J. Pettman and D.L. Massart
  Journal of Pharmaceutical and Biomedical Analysis 17 (1998), 141-152
  Read the abstract of this article
- Purity assessment and resolution of tetracycline hydrochloride samples analyzed using high-performance liquid chromatography with diode array detection
  K. De Braekeleer, A. de Juan and D.L. Massart
  Journal of Chromatography A 832 (1998), 67-86
  Read the abstract of this article
- On-line application of the orthogonal projection approach (OPA) and the soft independent modelling of class analogy approach (SIMCA) for the detection of the end point of a polymorph conversion reaction, by near infrared spectroscopy
  K. De Braekeleer, R. De Maesschalck, P.A. Hailey, D.C.A. Sharp and D.L. Massart
  Chemometrics and Intelligent Laboratory Systems 46 (1999), 103-116
  Read the abstract of this article
- Determination of the end point of a chemical synthesis process using on-line measured mid-infrared spectra
  K. De Braekeleer, A. de Juan, F. Cuesta Sánchez, P.A. Hailey, D.C.A. Sharp, P. Dunn and D.L. Massart
  Accepted for publication in Journal of Applied Spectroscopy
  Read the abstract of this article
- Improved purity assessment of high-performance liquid chromatography diode array detection data in the presence of the non-linearity artefact
  K. De Braekeleer, J.R. Torres-Lapasío and D.L. Massart
  Accepted for publication in Chemometrics and Intelligent Laboratory Systems
  Read the abstract of this article
- Nested designs in ruggedness testing
  Y. Vander Heyden, K. De Braekeleer, Y. Zhu, E. Roets, J. Hoogmartens, J. De Beer and D.L. Massart
  Journal of Pharmaceutical and Biomedical Analysis 20 (1999), 875-887
  Read the abstract of this article
- Application of several modified peak purity assays to real complex multicomponent mixtures by HPLC-DAD
  A. Garrido Frenich, J.R. Torres-Lapasío, K. De Braekeleer, D.L. Massart, J.L. Martínez Vidal and M. Martínez Galera
  Journal of Chromatography A 855 (1999), 487-499
  Read the abstract of this article
- Resolution of Multicomponent Peaks by multicomponentprojection approach, positive matrix factorization and alternating least squares
  A. Garrido Frenich, M. Martínez Galera, J.L. Martínez Vidal, D.L. Massart, J.R. Torres-Lapasío, K. De Braekeleer, Ji-Hong Wang and P.K. Hopke
  Analytica Chimica Acta, in press.
Oral Presentations
- Influence of temperature on NIR spectra
  6de Forum der Farmaceutische Wetenschappen; Floreal Club, Blankenberge, Belgium; 3/05/1996
- Influence and correction of temperature variation on NIR-spectra during a reaction monitoring process
  ChemoAC seminar; VUB, Jette; 14/05/1996
- Demonstration of a Matlab Toolbox for Mixture Analysis
  ChemoAC seminar; VUB, Jette; 14/05/1996
- The use of OPA and SIMPLISMA in other fields than hyphenated chromatography
  ChemoAC seminar; VUB, Jette; 15/01/1997
- Evaluation of the OPA and SIMPLISMA approach on the Windig standard spectral data sets
  7de Forum der Farmaceutische Wetenschappen; Floreal Club, Blankenberge, Belgium; 24/04/1997
- Alternating least squares
  ChemoAC seminar; VUB, Jette; 14/09/1998
- Multivariate techniques for purity assessment and pharmaceutical reaction monitoring
  Defense Phd thesis; VUB, Jette; 23/09/1999
- Multivariate curve resolution methods and their application to Raman analysis of pseudo-polymorphism
  ChemoAC seminar; VUB, Jette; 12/04/2000
Poster Presentations
- Influence and correction of temperature variation on NIR-spectra during a reaction monitoring process
  2nd Chemometrics symposium, Arenberg Castle K.U. Leuven, 27/09/1996
- The use of OPA and SIMPLISMA in other fields than hyphenated chromatography
  6th ChemoAC Seminar; VUB Jette; 15-16/01/97
- On-line application of the orthogonal projection approach (OPA) and the soft independent modelling of class analogy approach (SIMCA) for the detection of the end point of a polymorph conversion reaction, by NIR spectroscopy
  7th ChemoAC Seminar; VUB Jette; 19-20/06/1997
  3rd Chemometrics Symposium, Centre de Recherches Agronomiques Gembloux, 17/10/1997
- Detection of impurities in tetracycline using the HPLC method of the USP XXIII for the determination of tetracycline
  7th Meeting on Recent Developments in Pharmaceutical Analysis, Elba (Italy), 16-20/09/1997
- Evaluation of the orthogonal projection approach for the assessment of the purity of tetracycline hydrochloride in high performance liquid chromatography with diode array detection
  5th International Symposium on Hyphenated Techniques in Chromatography and Hyphenated Chromatographic Analyzers (HTC-5), 9-13/02/1998
- Determination of the end point of a chemical synthesis process including a significance level to determine the importance of the changes in the on-line measured mid-infrared spectra
  8th ChemoAC Seminar; VUB Jette, 17-18/02/1998
  Drug Analysis Symposium Brussels, 11-15/05/1998
- Determination of the end point of a chemical synthesis process using on-line measured mid-infrared spectra
  9th ChemoAC Seminar; VUB Jette, 14-15/09/1998
  4th Symposium of the Belgian Chemometrics Society, Tervuren, 20/11/1998
- Improved purity assessment of high-performance liquid chromatography diode array detection data in the presence of the non-linearity artefact
  10th ChemoAC Seminar; VUB Jette; 24-25/03/1999
- Guidance for the selection of multivariate techniques to study high-performance liquid chromatography dode array detection data
  11th ChemoAC Seminar; VUB Jette; 20-21/10/1999
Coordinates

Creation	Kris De Braekeleer	16-Dec-99
Last Update	Kris De Braekeleer	16-Dec-99
	hits on this page since	16-Dec-99
	hits on all pages since	24-Oct-95